The Derrick Rowley Lecture 2019

Richard Flavell

Professor Richard Flavell

The Derrick Rowley Lecture for 2019 will be presented on the topic of Mesenchymal cells in intestinal homeostasis, inflammation and cancer.


Mesenchymal cell populations, including fibroblasts, myofibroblasts, smooth muscle cells and pericytes, are a major but poorly investigated cellular component of the  intestinal microenvironment, interacting with intestinal epithelial cells, the extracellular matrix but also with immune cell types.

Intestinal mesenchymal cell types may be actively involved in the development, the resolution or the perpetuation of intestinal inflammatory responses in conditions such as Inflammatory Bowel Diseases. Mesenchymal cells can also be actively involved in the development of colorectal cancer.

The specific cell-to-cell interactions and the molecular pathways through which mesenchymal cell types exert their function in chronic inflammation and cancer remain largely unknown.

Recent studies addressing the role of intestinal mesenchymal cell types such as fibroblasts and myofibroblasts in intestinal homeostasis, inflammation and tumorigenesis as well as major open questions and current challenges in this field will be discussed.

Professor Flavell is Sterling Professor of Immunobiology at Yale University School of Medicine, and an Investigator of the Howard Hughes Medical Institute.

Tagged in Biological Sciences, For staff, For current students, For researchers, Molecular and biomedical science