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Tuesday October 6

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News: Honours projects - Chris Proud

Role of eEF2K & cancer cell migration & invasion

Cancer cells survive and gain the ability to spread under microenvironmental stress conditions through the inhibition of mTORC1 and subsequent activation of eEF2K

Honours project: Study cell signalling and gene regulation through the exploration of the role of eukaryotic elongation factor 2 kinase (eEF2K) and cancer cell migration and invasion.

[Read more about Role of eEF2K & cancer cell migration & invasion]

Systematic analysis of the eIF4E interactome

Active mTORC1 phosphorylates 4E-BP, preventing 4E1 binding. (B) mTORC1 inhibition leads to 4E-BP hypophosphorylation; 4E-BP now binds 4E1 and blocks eIF4F

Honours project: Conduct a systematic analysis of the eIF4E interactome to understand the distinct functional roles of the three mammalian eIF4E proteins in translation initiation.

[Read more about Systematic analysis of the eIF4E interactome]

Cellular-stress induced activation of non-TFEB regulated lysosomal genes

Cellular stress-induced transactivation of autophagy and lysosomal genes. In normal conditions, transcription factor EB (TFEB) is kept in the cytoplasm in an inactive form.

Honours project: Investigate the role of the eIF2α/ATF4 pathway in stress-induced transcription of non-TFEB genes.

[Read more about Cellular-stress induced activation of non-TFEB regulated lysosomal genes]

Exploring the functions of MAPK-interacting kinases (MNKs) in metabolic disease

MNKs play a key role in promoting adipocyte differentiation and this will be explored using the 3T3-L1 system

Honours project: Explore the functions of MAPK-interacting kinases (MNKs) in metabolic disease at the South Australian Health and Medical Research Institute.

[Read more about Exploring the functions of MAPK-interacting kinases (MNKs) in metabolic disease]

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