News: Honours projects - Molecular and biomedical science: Biochemistry

Making a bistable switch

Making a bistable switch

Honours project: This honours project involves the design, construction and testing of an activator based bistable switch.

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Role of HIFs in cancer

Decipher the specific roles of HIF1 and HIF2 in multiple myeloma.

Honours project: Decipher the specific roles of HIF1 and HIF2 in multiple myeloma.

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Directed evolution of proteins in vivo

Honours project: Use a new phage-based directed evolution approach to evolve proteins with properties to make them suitable for use in synthetic circuit applications, such as in vivo biosensing or construction of bistable switches.

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Synthetic phage therapy

Synthetic phage therapy

Honours project: Investigate the structural biology of bacteriophage proteins.

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Signalling pathways of epileptic seizures

Honours project: Explore the signalling pathways that induce NPAS4, which is highly induced in neurons during epileptic seizure, where it functions to dampen hyperexcitation.

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Structure determination of bHLH/PAS proteins

Honours project: This honours project will use analogous strategies to express, purify, crystallise and solve structures of mammalian bHLH/PAS proteins.

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Deciphering & exploiting bacterial cholesterol metabolism to combat disease

Deciphering & exploiting bacterial cholesterol metabolism to combat disease

Honours project: Address the fundamental science behind the use of the steroid cholesterol as a source of energy by bacteria.

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Role of eEF2K & cancer cell migration & invasion

Cancer cells survive and gain the ability to spread under microenvironmental stress conditions through the inhibition of mTORC1 and subsequent activation of eEF2K

Honours project: Study cell signalling and gene regulation through the exploration of the role of eukaryotic elongation factor 2 kinase (eEF2K) and cancer cell migration and invasion.

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Sim1 gene & its link to morbidly obese children

Honours project: Investigate Sim1 deficiency, a gene linked to severe childhood obesity and resultant from defects in satiety signalling in the hypothalamus.

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Systematic analysis of the eIF4E interactome

Active mTORC1 phosphorylates 4E-BP, preventing 4E1 binding. (B) mTORC1 inhibition leads to 4E-BP hypophosphorylation; 4E-BP now binds 4E1 and blocks eIF4F

Honours project: Conduct a systematic analysis of the eIF4E interactome to understand the distinct functional roles of the three mammalian eIF4E proteins in translation initiation.

[Read more about Systematic analysis of the eIF4E interactome]

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