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News: Honours projects - Molecular and biomedical science: Biochemistry

Making a bistable switch

Making a bistable switch

Honours project: This honours project involves the design, construction and testing of an activator based bistable switch.

[Read more about Making a bistable switch]

Role of HIFs in cancer

Decipher the specific roles of HIF1 and HIF2 in multiple myeloma.

Honours project: Decipher the specific roles of HIF1 and HIF2 in multiple myeloma.

[Read more about Role of HIFs in cancer]

Directed evolution of proteins in vivo

Honours project: Use a new phage-based directed evolution approach to evolve proteins with properties to make them suitable for use in synthetic circuit applications, such as in vivo biosensing or construction of bistable switches.

[Read more about Directed evolution of proteins in vivo]

Synthetic phage therapy

Synthetic phage therapy

Honours project: Investigate the structural biology of bacteriophage proteins.

[Read more about Synthetic phage therapy]

Deciphering & exploiting bacterial cholesterol metabolism to combat disease

Deciphering & exploiting bacterial cholesterol metabolism to combat disease

Honours project: Address the fundamental science behind the use of the steroid cholesterol as a source of energy by bacteria.

[Read more about Deciphering & exploiting bacterial cholesterol metabolism to combat disease]

Role of eEF2K & cancer cell migration & invasion

Cancer cells survive and gain the ability to spread under microenvironmental stress conditions through the inhibition of mTORC1 and subsequent activation of eEF2K

Honours project: Study cell signalling and gene regulation through the exploration of the role of eukaryotic elongation factor 2 kinase (eEF2K) and cancer cell migration and invasion.

[Read more about Role of eEF2K & cancer cell migration & invasion]

Systematic analysis of the eIF4E interactome

Active mTORC1 phosphorylates 4E-BP, preventing 4E1 binding. (B) mTORC1 inhibition leads to 4E-BP hypophosphorylation; 4E-BP now binds 4E1 and blocks eIF4F

Honours project: Conduct a systematic analysis of the eIF4E interactome to understand the distinct functional roles of the three mammalian eIF4E proteins in translation initiation.

[Read more about Systematic analysis of the eIF4E interactome]

Exploring the functions of MAPK-interacting kinases (MNKs) in metabolic disease

MNKs play a key role in promoting adipocyte differentiation and this will be explored using the 3T3-L1 system

Honours project: Explore the functions of MAPK-interacting kinases (MNKs) in metabolic disease at the South Australian Health and Medical Research Institute.

[Read more about Exploring the functions of MAPK-interacting kinases (MNKs) in metabolic disease]

CRISPR therapy development

Honours project: This genome editing project focuses on developing CRISPR gene therapy for Duchenne Muscular Dystrophy (DMD).

[Read more about CRISPR therapy development]

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