Molecular Virology Group research focuses on virus-host interactions and viral genome replication for the related Flaviviridae family viruses hepatitis C, dengue and Zika.
We seek to develop and apply novel reporter virus tools, sensitive and minimally invasive high-resolution imaging and sensing techniques and targeted and random manipulation of infectious viral genomes.
This helps us better understand the viral and host determinants of viral replication compartment formation, morphology and function and how viral replication complexes interact with virus assembly platforms.
We also employ functional genomics and drug library screens to identify host factors and pathways that are co-opted by these viruses. This allows us to also identify and investigate novel antiviral therapeutic compounds and strategies.
Funding for our research comes from NHMRC, Channel 7 Children’s Research Foundation and the Australian Centre for HIV and Hepatitis Virology (ACH2).
Positive-strand RNA viruses ([+]RNA viruses) represent >30% of all known viruses and infect almost all eukaryotic organisms, animals and plants.
Among other families of [+]RNA viruses, members of the Flaviviridae family include major human pathogens such as dengue virus (DENV), hepatitis C virus (HCV), West Nile virus (WNV) and Zika virus (ZIKV).
Research in the Molecular Virology Group aims to identify viable pathways for the development of safe and effective antiviral strategies to combat the spread and impact of these viruses.
We hope to achieve this by identifying and dissecting the features of viral proteins and virus-host interactions that are essential for the viral replication cycle; and high-throughput drug screening strategies.
People and publications
Study with us
PhD, honours, masters and research placement projects are available in the areas of:
- High-resolution imaging of DENV infection
- High-throughput mutagenesis of the DENV genome
- High-throughput screening of candidate antiviral drugs
- Identification of host dependency factors via functional genomic screens
- Development and application of novel fluorescent and luminescent sensors to study viral replication and virus-host interactions
Please contact our laboratory head to discuss available projects.