Honours information session

Thursday May 6 2.30pm

Join us for a short online session to discover why honours could be the right choice for you.

Register for webinar

Optimisation of chimeric antigen receptor immunotherapy: building a better car?

Undertake an honours project in the construction and evaluation of a novel Chimeric Antigen Receptor T cell targeting a solid tumour antigen.

CAR-T cells have demonstrated robust clinical activity against B-cell cancer, although they also cause B cell aplasia. However, it has been noted that perhaps the greatest challenge to the field of engineered T cell therapy is the identification of a ‘universal’ CAR-T, that is, a CAR-T cell that can attack a broad range of cancers, especially solid cancers.

We have identified and tested a cancer target that we believe has the potential to meet this challenge. P2X7 is a human cell surface protein that, when functioning normally, controls programmed cell death in old or damaged cells.

A dysfunctional version of P2X7, named nfP2X78, has been identified on cancer cells from a wide variety of tissues, including brain, prostate, breast, melanoma, bowel, ovary, cervix, lung, pancreas and stomach, while being completely absent on healthy cells.

We propose that a CAR-T cell targeting nfP2X7 could attack a broad range of solid cancers and have little, if any, off-cancer damage.

We have already generated prototype nfP2X7 targeted CAR-T cells and have data showing that these CAR-T cells can kill several solid cancer cell types in the laboratory. this project will develop and test new CAR-T constructs.

Professor Simon Barry

Supervisors

Professor Simon Barry

Co-supervisor: Tim Sadlon - Women's and Children's Hospital | Dr Veronika Bandara

Research area: Molecular immunology

Recommended honours enrolment: Honours in Molecular and Biomedical Science

Tagged in Honours projects - Molecular and biomedical science, Honours projects - Simon Barry, Honours projects - Tim Sadlon, Honours projects - Veronika Bandara, Honours projects - Molecular and biomedical science: Genetics

STEM Careers Night: On-campus and online

Whether you're still at high school or planning to join us mid-year, taking a break from study or rethinking your career path, come chat with us at our STEM Careers Night.

You and your parents are invited to join us on campus on Tuesday 18 May to see what’s available in the world of STEM.

STEM Careers Night