Honours information session

Thursday May 6 2.30pm

Join us for a short online session to discover why honours could be the right choice for you.

Register for webinar

CRISPR genome wide screens & viral replication

Use CRISPR/Cas9 genome wide screens to identify viral host dependency factors and novel innate immune genes that control viral replication.

CRISPR/Cas9 technology is a powerful molecular tool to target to a specific gene for deletion and has revolutionised our ability to genetically manipulate cells.

Our laboratory has used a CRISPR/Cas9 genome wide screen in which guide-RNAs (approximately 122,000 delivered by lentiviral transduction) representing the complete human genome are introduced into cultured cells to selectively knock out cellular genes.

Using this technology followed by viral infection (ZIKV) we have identified novel essential host factors for viral replication such as the cellular protein RACK1. Interestingly, RACK1 is important for the replication of all Flaviviridae but not Ebola, MERS or DNA viruses suggesting selectivity in its action.

We are currently applying CRISPR/Cas9 genome wide screens to other viruses such as HCV and to identify novel genes that control virus replication in response to interferon stimulation.

Associate Professor Michael Beard


Associate Professor Michael Beard

Research area: Viral pathogenesis, Research Centre for Infectious Diseases

Recommended honours enrolment: Honours in Molecular and Biomedical Science

Tagged in Honours projects - Molecular and biomedical science, Honours projects - Michael Beard, Honours projects - Molecular and biomedical science: Microbiology and immunology

STEM Careers Night: On-campus and online

Whether you're still at high school or planning to join us mid-year, taking a break from study or rethinking your career path, come chat with us at our STEM Careers Night.

You and your parents are invited to join us on campus on Tuesday 18 May to see what’s available in the world of STEM.

STEM Careers Night