Honours information session

Thursday May 6 2.30pm

Join us for a short online session to discover why honours could be the right choice for you.

Register for webinar

Directed evolution of proteins in vivo

In this project, a new phage-based directed evolution approach will be used to evolve proteins with properties to make them suitable for use in synthetic circuit applications, such as in vivo biosensing or construction of bistable switches.

Directed evolution allows for the rapid selection of new protein function. By iterative rounds of mutagenesis and selection under conditions which favour the desired property/activity, variants can be selected from a large library without any requiring detailed structural information.

A recently published method for directed evolution using filamentous phage should allow a wide variety of selection schemes to be employed. For example, it should be possible to convert a transcriptional repressor into a transcriptional activator, or to improve the strength of a particular protein-protein interaction.

Keith Shearwin


Associate Professor Keith Shearwin

Co-supervisor: Dr Nan Hao

Research area:  Synthetic biology, biochemistry, genetics and mathematical modelling

Recommended honours enrolment: Honours in Molecular and Biomedical Science

Tagged in Honours projects - Molecular and biomedical science, Honours projects - Keith Shearwin, Honours projects - Nan Hao, Honours projects - Molecular and biomedical science: Biochemistry

STEM Careers Night: On-campus and online

Whether you're still at high school or planning to join us mid-year, taking a break from study or rethinking your career path, come chat with us at our STEM Careers Night.

You and your parents are invited to join us on campus on Tuesday 18 May to see what’s available in the world of STEM.

STEM Careers Night