Early Origins of Breast and Prostate Cancer
Explore maternal nutrition, developmental origins of disease, cancer and epigenetics through molecular genetics
It is well known that maternal complications during pregnancy can impact the short and long-term health of offspring. In particular, uteroplacental insufficiency during pregnancy can predispose offspring who are born small to an increased risk of developing chronic disease later in life such as obesity, diabetes, cardiovascular disease or cancer. In addition, overnutrition of the mother or father prior to and during pregnancy programs offspring disease risk.
Using samples collected from previous animal studies, our research objective is to determine if pregnancy complications alter prostate or mammary gland development in offspring, leading to an increased susceptibility of developing cancer in adult life. Given that obesity is a growing epidemic world-wide, understanding how obesity can influence the development and progression of cancer will help identify targets for intervention and prevention. We are also investigating the molecular mechanisms involved.
In summary, this project will ideally suit an enthusiastic student who is interested in learning more about maternal nutrition, developmental origins of disease, cancer and epigenetics.
You will develop skills in:
- DNA and RNA Extractions
- Quantitative Real Time PCR
- DNA Methylation Analyses
- Chiam K, Tilley WD, Butler LM, Bianco-Miotto T. The dynamic and static modification of the epigenome by hormones: a role in the developmental origin of hormone related cancers. Biochim Biophys Acta. 2009; 1795(2):104-9.
- Mahizir D, Briffa JF, Hryciw DH, Wadley GD, Moritz KM, Wlodek ME. Maternal obesity in females born small: Pregnancy complications and offspring disease risk. Mol Nutr Food Res. 2016; 60(1):8-17.
- Cheong JN, Wlodek ME, Moritz KM, Cuffe JS. Programming of maternal and offspring disease: impact of growth restriction, fetal sex and transmission across generations. J Physiol. 2016; 594(17):4727-40