Oral vs intrarectal Emu Oil administration & protection against Crohn’s disease in mice

Investigate if Emu Oil - administered via oral or intrarectal route - is capable of reducing the impact of Crohn’s disease in mice.

Granulomas in an intestinal lymph node in Crohn's disease

Granulomas in an intestinal lymph node in Crohn's disease
Patho [CC BY-SA 3.0]

Crohn’s disease is an idiopathic, incurable bowel disorder characterised by transmural inflammation throughout the intestinal tract.

Previously, we demonstrated the anti-inflammatory and reparative properties of orally-administered Emu Oil in animal models of intestinal disease, including acute Crohn’s disease.

It is important to determine any differences in efficacy of orally-administered Emu Oil (following metabolism) versus intrarectally administered Emu Oil (local unmetabolised effect) in this setting. 

Key methodology:

  • Animal trial (daily monitoring, disease activity index, behavioural measures, colonoscopically-assessed disease severity)
  • Biochemical analysis (myeloperoxidase activity)
  • Histological analyses (quantitative and qualitative)
  • Intestinal permeability (FITC-D)
Suzanne Mashtoub

Supervisors

Dr Suzanne Mashtoub

Co-supervisors: Professor Gordon Howarth

Research area: Pathobiology, infectious disease & public health

Recommended honours enrolment: Honours in Animal Science

Tagged in Honours projects - Animal science, Honours projects - Molecular and biomedical science, Honours in Animal Science subtheme - Pathobiology infectious disease and public health, Honours projects - Suzanne Mashtoub, Honours projects - Gordon Howarth, Honours projects - Molecular and biomedical science: Other