Can Emu Oil & Japanese Kampo medicine treat bowel cancer?
Examine the impact of Emu Oil treatment, in combination with Japanese Kampo medicine, on mouse behaviour in a model of colitis-associated colorectal cancer.
This project seeks to determine behavioural modifications resulting from combined Emu Oil and Kampo treatment in a mouse model of colitis-associated colorectal cancer.
Ulcerative colitis, a type of inflammatory bowel disease, is a lifelong condition characterised by unremitting inflammation of the distal bowel. Persistent inflammation causes cells to grow uncontrollably, resulting in colorectal cancer.
Previously, we demonstrated the anti-inflammatory and reparative properties of orally-administered Emu Oil in animal models of intestinal disease.
The impact of a combined therapy of Emu Oil with Kampo medicine (a traditional Japanese herbal medicine) on mouse behaviour is yet to be investigated.
Key methodology: You will co-run a 9-week mouse study assessing different aspects of behaviour including burrowing, nesting and facial grimace of mice.
Study pathobiology, infectious disease & public health
Dr Mashtoub leads a research group at the Women’s and Children’s Hospital, specialising in animal models of intestinal disease.
Dr Mashtoub’s group investigates the efficacy of Emu Oil in combination with other nutraceuticals, as part of the Digestive Health Research Group.