Role of Flii protein in colitis-associated colorectal cancer development
We're seeking to understand the role of Flightless I (Flii) protein in colitis-associated colorectal cancer development.
Ulcerative colitis, a type of inflammatory bowel disease, is a lifelong condition characterised by unremitting inflammation of the distal bowel. Persistent inflammation causes cells to grow uncontrollably, resulting in colorectal cancer.
Previous studies have identified a novel protein present at high levels in gastrointestinal tract of humans and mice with colitis which contributes to disease severity. Moreover, this protein affects cancer development in the skin.
It is hypothesised that mice with high levels of this harmful protein will have higher quicker onset and more severe development of colon cancer.
As such, this project will examine the effect of altered Flii gene levels on development of colitis-associated colorectal cancer in mice.
- Animal trial - daily monitoring, disease activity index, colonoscopically-assessed disease severity.
- Biochemical analysis - myeloperoxidase activity
- Histological analyses - quantitative and qualitative
- Intestinal permeability - FITC-D
Study pathobiology, infectious disease & public health
Dr Mashtoub leads a research group at the Women’s and Children’s Hospital, specialising in animal models of intestinal disease.
Dr Mashtoub’s group investigates the efficacy of Emu Oil in combination with other nutraceuticals, as part of the Digestive Health Research Group.