Role of Flii protein in colitis-associated colorectal cancer development

We're seeking to understand the role of Flightless I (Flii) protein in colitis-associated colorectal cancer development.

Ulcerative colitis, a type of inflammatory bowel disease, is a lifelong condition characterised by unremitting inflammation of the distal bowel. Persistent inflammation causes cells to grow uncontrollably, resulting in colorectal cancer.

Previous studies have identified a novel protein present at high levels in gastrointestinal tract of humans and mice with colitis which contributes to disease severity. Moreover, this protein affects cancer development in the skin. 

It is hypothesised that mice with high levels of this harmful protein will have higher quicker onset and more severe development of colon cancer.

As such, this project will examine the effect of altered Flii gene levels on development of colitis-associated colorectal cancer in mice.

Key methodology:

  • Animal trial - daily monitoring, disease activity index, colonoscopically-assessed disease severity.
  • Biochemical analysis - myeloperoxidase activity
  • Histological analyses - quantitative and qualitative
  • Intestinal permeability - FITC-D
Suzanne Mashtoub

Supervisors

Dr Suzanne Mashtoub

Co-supervisors: Dr Zlatko Kopecki - UniSA | Professor Gordon Howarth

Research area: Pathobiology, infectious disease & public health

Recommended honours enrolment: Honours in Animal Science

Tagged in Honours projects - Animal science, Honours projects - Molecular and biomedical science, Honours in Animal Science subtheme - Pathobiology infectious disease and public health, Honours projects - Suzanne Mashtoub, Honours projects - Gordon Howarth, Honours projects - Molecular and biomedical science: Other