Kinetics & thermodynamics of biomimetic mineralisation

Metal-organic frameworks (MOFs) are highly porous materials synthesised via a ‘building block’ approach from organic linkers and metal nodes, which offers control of chemical functionality, pore shape and size, and crystal morphology.

Biomimetic mineralisation

These mutable properties have facilitated applications in biologically related fields.

Recently, we showed that biomacromolecules can induce the growth of MOFs in aqueous solution to afford a robust coating that offers protection from typically destructive environments such as elevated temperatures and proteolytic enzymes.

This process, termed biomimetic mineralisation, does not require a co-precipitant and has been extended to other biological entities such as viruses and cells. Interest in this technique is burgeoning due to its potential for application to areas including industrial biocatalysis and biotechnology.

Projects include:

  • Investigating the influence of the presence of biomolecules on the kinetics of MOF assembly using nucleation theory and kinetic modelling.
  • Studying the impact of biomolecule‚ÄìMOF interactions on biomolecule stability and activity using statistical thermodynamics and molecular simulations.

David Huang

Supervisor

Associate Professor David Huang

Research area: Theoretical chemistry, computational chemistry, physical chemistry, chemical physics

Recommended honours enrolmentHonours in Chemistry

Tagged in Honours projects - Chemistry, Honours Projects - David Huang