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Understanding the molecular mechanisms of intellectual disability

This research project explores the molecular mechanisms of intellectual disability

Mutations in IQSEC2 lead to substantial limitation in intellectual functioning and adaptive behaviour in children, including speech disturbances, autistic traits and seizures. 

To better investigate the role of this gene, we have generated a novel mouse modelling the complete knockout (KO) of IQSEC2; which presents with frequent and recurrent seizures. Hippocampal neurons extracted from IQSEC2-KO embryos grown in culture display a morphological phenotype when compared to their healthy wild-type (WT) counterparts. 

This project will use this resource to investigate the role IQSEC2 and synaptic morphology and plasticity on the orchestration of the complex architecture required for ‘normal’ cognition.


Tagged in Honours projects - Molecular and biomedical science, Honours projects - Cheryl Shoubridge, Honours projects - Molecular and biomedical science: Genetics

STEM Careers Night: On-campus and online

Whether you're still at high school or planning to join us mid-year, taking a break from study or rethinking your career path, come chat with us at our STEM Careers Night.

You and your parents are invited to join us on campus on Tuesday 18 May 2021 to see what’s available in the world of STEM.

STEM Careers Night