Honours information session

Thursday May 6 2.30pm

Join us for a short online session to discover why honours could be the right choice for you.

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Monitoring of minimal residual disease on chronic myeloid leukaemia patients in a setting of treatment free remission

For patients who have achieved deep molecular responses and have minimal residual disease after treatment, the new goal for clinicians today is to identify candidate patients that can safely cease TKI therapy achieving treatment free remission (TFR).

hughes honours myeloid leukaemia

It is estimated that approximately 50% of CML patients may be eligible to stop TKIs, however half of them experience molecular relapse, usually within 6 months, and have to restart therapy. CML is projected to become the most prevalent leukaemia by 2040, therefore is critical to maximise the number of patients achieving TFR.

However, unravelling the critical mediators of TFR is a major challenge.

The aim of the project will be to characterise the residual leukaemia population in TFR patients, and understand why some patients relapse and others don’t.

One possible line of inquiry involves identifying the lineage of residual CML cells, through a highly sensitive DNA approach. This will involve a characterisation of the genomic breakpoint and the development of a patient-specific assay to monitor residual leukaemia on sorted cell populations.

Professor Tim Hughes

Supervisors

Professor Timothy Hughes

Co-supervisorsDr Ilaria Pagani

Research area: Cancer program - South Australian Health and Medical Research Institute

Recommended honours enrolment: Honours in Molecular and Biomedical Science

Tagged in Honours projects - Molecular and biomedical science, Honours projects - Molecular and biomedical science: Microbiology and immunology, Honours projects - Timothy Hughes, Honours projects - Ilaria Pagani

STEM Careers Night: On-campus and online

Whether you're still at high school or planning to join us mid-year, taking a break from study or rethinking your career path, come chat with us at our STEM Careers Night.

You and your parents are invited to join us on campus on Tuesday 18 May to see what’s available in the world of STEM.

STEM Careers Night