Sim1 gene & its link to morbidly obese children

This research project explores Sim1 deficiency, a gene linked to severe childhood obesity and resultant from defects in satiety signalling in the hypothalamus.

In collaboration with a Cambridge University team studying the genetics of obesity, we are analysing several point mutants of the Sim1 gene that have been found in morbidly obese children.

Our studies include creating Sim1 point mutant knock-in mice for physiological assays, analyses of protein malfunction in cultured cells and structural studies of pure, recombinant wt and mutant proteins.

Murray Whitelaw

Supervisor

Professor Murray Whitelaw

Research area: Biochemical responses to environmental and physiological stress

Recommended honours enrolment: Honours in Molecular and Biomedical Science

Tagged in Honours projects - Molecular & biomedical science, Honours projects - Murray Whitelaw