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Understanding T cells in autoimmune disease

Join the Chemokine Biology Lab for a science honours project investigating transcriptional control of inflammatory T helper cells in autoimmunity.

CD4+ T cells play a critical role in autoimmune inflammation such as multiple sclerosis (MS) by producing pro-inflammatory cytokines in response to recognition of tissue antigens.

Recent data indicate that Th cells that co-produce the cytokines GM-CSF and IL-17A are potently inflammatory, but little is known regarding the development of these cells in vivo.

Honours Iain Comerford Fig X

RNA sequencing of these cells has highlighted 2 transcription factors that are associated with this subset of T cells, namely RUNX2 and ID2. In this project we will utilise novel conditional knock-out mice that lack either Runx2 or Id2 in mature T cells to determine the role of these two transcription factors in inflammatory Th cell development and function.

The project will involve mouse models of autoimmunity, in vitro T cell activation cell culture, multi-parameter flow cytometry, RNA sequencing, RT-qPCR and molecular biology.

References


 

Supervisors

Dr Iain Comerford

Co-supervisorProfessor Shaun McColl

Research area: Chemokine Biology Lab, School of Biological Sciences

Recommended honours enrolment: Honours in Molecular and Biomedical Science

Tagged in Honours projects - Molecular and biomedical science, Honours projects - Molecular and biomedical science: Microbiology and immunology, Honours projects - Iain Comerford, Honours projects - Shaun McColl