Invasive bacterial pathogens
The Invasive Bacterial Pathogens Laboratory conducts research into an enteric and invasive bacterial pathogens with a focus on the role of bacterial cell surface molecules in bacterial pathogenesis.
Our key areas of research are:
- Structure and function of the Shigella flexneri IcsA protein.
- S. flexneri actin based motility and cell to cell spread.
- Biosynthesis of S. flexneri lipopolysaccharide O antigens.
- Structure and function of Polysaccharide Co-polymerase proteins
- Novel anti-virulence drugs to prevent bacterial diseases
We also have collaborative research interests in:
- Biosynthesis and regulation Streptococcus pneumoniae capsule biosynthesis
- Receptor mimic technology
- Development of Biotin Protein Ligase inhibitors
Bacterial pathogens are the cause of significant morbidity and mortality worldwide. Efforts to develop new and novel therapies focus on identification of new drug targets, and understanding the mechanisms and molecules that lead to pathogenesis and disease.
The pathogen that is the focus of our research is Shigella flexneri, the causative agent of bacillary dysentery. Bacterial cell surface molecules are important mediators of interaction between bacteria and hosts, and their structure, function and biogenesis are of particular interest.