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Deciphering the catalytic potential & the electron transfer pathways of microorganisms
Honours project: Study new enzymes and the associated ferredoxins from bacteria found in interesting environments (or genes from metagenomes) or which carry out novel reactions.
Synthetic biology applications of enzymes
Honours project: Use approaches to generate enzyme catalyst based systems to develop greener and sustainable processes for the production of useful and high value chemicals.
Deciphering & exploiting bacterial cholesterol metabolism to combat disease
Honours project: Address the fundamental science behind the use of the steroid cholesterol as a source of energy by bacteria.
[Read more about Deciphering & exploiting bacterial cholesterol metabolism to combat disease]
Behavioural analysis of zebrafish models of Alzheimer's Disease
Honours project: Undertake behavioural analysis of zebrafish models in order to help find treatments for Alzheimer's Disease.
[Read more about Behavioural analysis of zebrafish models of Alzheimer's Disease]
Directed evolution of proteins in vivo
Honours project: Use a new phage-based directed evolution approach to evolve proteins with properties to make them suitable for use in synthetic circuit applications, such as in vivo biosensing or construction of bistable switches.
Structure determination of bHLH/PAS proteins
Honours project: This honours project will use analogous strategies to express, purify, crystallise and solve structures of mammalian bHLH/PAS proteins.
[Read more about Structure determination of bHLH/PAS proteins]
Signalling pathways of epileptic seizures
Honours project: Explore the signalling pathways that induce NPAS4, which is highly induced in neurons during epileptic seizure, where it functions to dampen hyperexcitation.
Structural basis for nuclear receptor allostery
Honours project: Gain a stronger understanding of general receptor allostery as well as structure guided drug design.
[Read more about Structural basis for nuclear receptor allostery]
Bioinformatic analysis of zebrafish models of Alzheimer's Disease
Honours project: This project involves the bioinformatic analysis of zebrafish models of Alzheimer's Disease.
[Read more about Bioinformatic analysis of zebrafish models of Alzheimer's Disease]
Fungal structural genomics
Honours project: Probe essential protein mechanisms by biophysical methods including x-ray crystallography with structure guided drug design in mind.
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