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Structural basis for nuclear receptor allostery

 Structural basis for nuclear receptor allostery

Honours project: Gain a stronger understanding of general receptor allostery as well as structure guided drug design.

[Read more about Structural basis for nuclear receptor allostery]

Bioinformatic analysis of zebrafish models of Alzheimer's Disease

Bioinformatic analysis of zebrafish models of Alzheimer's Disease

Honours project: This project involves the bioinformatic analysis of zebrafish models of Alzheimer's Disease.

[Read more about Bioinformatic analysis of zebrafish models of Alzheimer's Disease]

Deciphering & exploiting bacterial cholesterol metabolism to combat disease

Deciphering & exploiting bacterial cholesterol metabolism to combat disease

Honours project: Address the fundamental science behind the use of the steroid cholesterol as a source of energy by bacteria.

[Read more about Deciphering & exploiting bacterial cholesterol metabolism to combat disease]

Structure determination of bHLH/PAS proteins

Honours project: This honours project will use analogous strategies to express, purify, crystallise and solve structures of mammalian bHLH/PAS proteins.

[Read more about Structure determination of bHLH/PAS proteins]

Behavioural analysis of zebrafish models of Alzheimer's Disease

We’re undertaking behavioural analysis of zebrafish models in order to help find treatments for Alzheimer's Disease.

Honours project: Undertake behavioural analysis of zebrafish models in order to help find treatments for Alzheimer's Disease.

[Read more about Behavioural analysis of zebrafish models of Alzheimer's Disease]

Role of HIFs in cancer

Decipher the specific roles of HIF1 and HIF2 in multiple myeloma.

Honours project: Decipher the specific roles of HIF1 and HIF2 in multiple myeloma.

[Read more about Role of HIFs in cancer]

Directed evolution of proteins in vivo

Honours project: Use a new phage-based directed evolution approach to evolve proteins with properties to make them suitable for use in synthetic circuit applications, such as in vivo biosensing or construction of bistable switches.

[Read more about Directed evolution of proteins in vivo]

Synthetic phage therapy

Synthetic phage therapy

Honours project: Investigate the structural biology of bacteriophage proteins.

[Read more about Synthetic phage therapy]

Signalling pathways of epileptic seizures

Honours project: Explore the signalling pathways that induce NPAS4, which is highly induced in neurons during epileptic seizure, where it functions to dampen hyperexcitation.

[Read more about Signalling pathways of epileptic seizures]

Identifying new drugs that kill parasites

Honours project: Work with a team of researchers who are identifying and characterising novel drugs that kill apicomplexan parasites.

[Read more about Identifying new drugs that kill parasites]

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